Phenolic compounds versus SARS-CoV-2: An update on the main findings against COVID-19 (5.0)

Hernández Martínez,Ernesto

Phenolic compounds versus SARS-CoV-2: An update on the main findings against COVID-19 (5.0)

dc.contributor.author	Hernández Martínez,Ernesto
dc.date.accessioned	2026-03-09T20:57:59Z
dc.date.available	2026-03-09T20:57:59Z
dc.date.issued	2022-09-14
dc.description.abstract	The COVID-19 pandemic caused by SARS-CoV-2 remains an international concern. Although there are drugs to fight it, new natural alternatives such as polyphenols are essential due to their antioxidant activity and high antiviral potential. In this context, this review reports the main findings on the effect of phenolic compounds (PCs) against SARS-CoV-2 virus. First, the proven activity of PCs against different human viruses is briefly detailed, which serves as a starting point to study their anti-COVID-19 potential. SARS-CoV-2 targets (its proteins) are defined. Findings from in silico, in vitro and in vivo studies of a wide variety of phenolic compounds are shown, emphasizing their mechanism of action, which is fundamental for drug design. Furthermore, clinical trials have demonstrated the effectiveness of PCs in the prevention and as a possible therapeutic management against COVID-19. The results were complemented with information on the influence of polyphenols in strengthening/modulating the immune system. It is recommended to investigate compounds such as vitamins, minerals, alkaloids, triterpenes and fatty acids, and their synergistic use with PCs, many of which have been successful against SARS-CoV-2. Based on findings on other viruses, synergistic evaluation of PCs with accepted drugs against COVID-19 is also suggested. Other recommendations and limitations are also shown, which is useful for professionals involved in the development of efficient, safe and low-cost therapeutic strategies based on plant matrices rich in PCs. To the authors' knowledge, this manuscript is the first to evaluate the relationship between the antiviral and immunomodulatory (including anti-inflammatory and antioxidant effects) activity of PCs and their underlying mechanisms in relation to the fight against COVID-19. It is also of interest for the general population to be informed about the importance of consuming foods rich in bioactive compounds for their health benefits
dc.format	application/pdf
dc.identifier.doi	https://doi.org/10.3389/fsufs.2022.901417
dc.identifier.uri	http://hdl.handle.net/20.500.14689/1121
dc.language.iso	eng
dc.publisher	Helyon
dc.publisher.country	GB
dc.rights	info:eu-repo/semantics/openAccess
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/2.5/pe/
dc.source	Universidad Nacional de Jaén\|\|Repositorio Institucional - UNJ
dc.subject	Coronavirus
dc.subject	SARSCoV
dc.subject	Peru
dc.subject	food supply chain
dc.subject	food system
dc.subject	food and nutrition security
dc.subject	sustainabilit Polyphenols
dc.subject	SARS-CoV-2
dc.subject	COVID-19
dc.subject	Medicine natural
dc.subject	Immune system
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#2.11.01
dc.title	Phenolic compounds versus SARS-CoV-2: An update on the main findings against COVID-19 (5.0)
dc.type	info:eu-repo/semantics/article
dc.type.version	info:eu-repo/semantics/publishedVersion
renati.author.dni	16735303